ABSTRACT
PURPOSE: Feeding children is a problem in pediatric intensive care units (PICU) and it is difficult to know the correct amount. The purpose of this study is to evaluate if prealbumin or retinol binding proteins (RBP) are effective relative to daily enteral nutrition, without being affected by severity of diseases or infections and can be used to follow up nutritional amount. METHODS: This is a prospective observational study that includes 81 patients admitted to PICU in Akdeniz University with estimated duration >72 hours, age between 1 month and 8 years. Daily calorie and protein intake were calculated and prealbumin, RBP and C-reactive protein (CRP) levels were measured on the first, third, fifth and seventh mornings. RESULTS: We find moderate correlation between daily calorie intake and prealbumin levels (r=0.432, p < 0.001), RBP levels and daily protein intake (r=0.330, p < 0.001). When we investigated the relationship between changes of prealbumin, RBP, CRP, calorie and protein intake during intensive care stay, we found that increase of Prealbumin and RBP levels are explained by decrease of CRP levels (r=−0.546 and −0.645, p < 0.001) and not with increase of nourishment. CONCLUSION: Even adjusted for PRISM3, age and CRP, prealbumin and RBP are correlated with last 24 hours' diet. However, it is not convenient to use as a follow up biomarker because increase of their levels is related with decrease of CRP levels.
Subject(s)
Child , Humans , C-Reactive Protein , Critical Care , Critical Illness , Diet , Enteral Nutrition , Follow-Up Studies , Intensive Care Units , Intensive Care Units, Pediatric , Nutritional Status , Observational Study , Prealbumin , Prospective Studies , Retinol-Binding Proteins , Vitamin AABSTRACT
Objectives: red cell distribution width [RDW] and neutrophil-to-lymphocyte ratio [NLR] are the two markers used to determine risk of mortality and adverse cardiovascular outcomes in patients with acute myocardial infarction. The relationship between RDW, NLR, and left ventricular [LV] systolic functions has not been reported. In this report, we aimed to investigate the relationship between RDW, NLR, and LV systolic function in anterior ST-segment elevation myocardial infarction [STEMI] patients who underwent primary percutaneous coronary intervention [PCI]
Methods: RDW and NLR were measured on admission in 106 STEMI patients treated with primary PCI. Patients were divided into two groups according to left ventricular ejection fraction [LVEF], as Group I [systolic dysfunction, LVEF <50%] and Group II [preserved global left ventricle systolic function, LVEF P50%]. The first group included 47 patients and the second group included 59 patients
Results: mean RDW and NLR were significantly higher in Group I compared to Group II [13.7 +/- 0.9% vs. 13.4 +/- 0.7%, p = 0.03 and 5.86 [range, 0.66-40.50] vs. 2.75 [range, 0.51-39.39], p = 0.013, respectively]
Conclusion: increased RDW and NLR on admission, in anterior STEMI patients treated with primary PCI are associated with LV systolic dysfunction